Two new quaternary protoberberine alkaloids from Corydalis yanhusuo

被引：27

作者：

Zhou, Qiong ^{[1
,2
]}

Deng, An-Jun ^{[1
,2
]}

Qin, Hai-Lin ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 05期

关键词：

Corydalis yanhusuo; Papaveraceae; quaternary protoberberine alkaloid; corydayanine; yanhusuine;

D O I：

10.1080/10286020.2012.677038

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new quaternary protoberberine alkaloids, namely corydayanine (1) and yanhusuine (2), were isolated from the tubers of Corydalis yanhusuo. On the basis of extensive chemical and spectroscopic evidences, especially 1D and 2D NMR and HRMS experiments, their structures were elucidated as 5,6-dihydro-3,9-dihydroxy-2,10-dimethoxy- 13-methyl-dibenzo[a,g] quinolizinium alkaloid and 5,6-dihydro-12-hydroxy- 2,3,9-trimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid, respectively.

引用

页码：476 / 481

页数：6

共 9 条

[1]

Two new protoberberine quaternary alkaloids from Corydalis yanhusuo [J].

Cheng, Xing-Ye ;

Shi, Yue ;

Zheng, Shun-Liang ;

Jin, Wen ;

Sun, Hong .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 10 (12) :1117-1121

[2]

Fu X.-Y., 1986, ACTA PHARM SIN, V21, P447, DOI 10.16438/j.0513-4870.1986.06.008

[3]

[贺凯 HE Kai], 2007, [中草药, Chinese Traditional and Herbal Drugs], V38, P1909

[4]

Hu Tiantian, 2009, Zhongguo Zhong Yao Za Zhi, V34, P1917

[5]

In vitro cytotoxicity of the protoberberine-type alkaloids [J].

Iwasa, K ;

Moriyasu, M ;

Yamori, T ;

Turuo, T ;

Lee, DU ;

Wiegrebe, W .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (07) :896-898

[6]

SHAMMA M, 1972, ISOQUINOLINE ALKALOI, P308

[7]

PROTOBERBERINE ALKALOIDS AS ANTIMALARIALS [J].

VENNERSTROM, JL ;

KLAYMAN, DL .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (06) :1084-1087

[8]

[许翔鸿 Xu Xianghong], 2002, [中国药科大学学报, Journal of China Pharmaceutical University], V33, P483

[9]

[张晓丽 ZHANG Xiaoli], 2008, [沈阳药科大学学报, Journal of Shenyang Pharmaceutical University], V25, P537

← 1 →