In vitro cytotoxicity of the protoberberine-type alkaloids

被引:95
作者
Iwasa, K
Moriyasu, M
Yamori, T
Turuo, T
Lee, DU
Wiegrebe, W
机构
[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan
[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Toyoshima Ku, Tokyo 1708455, Japan
[3] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130000, Japan
[4] Dongguk Univ, Coll Nat Sci, Dept Biochem, Kyongju 780714, Kyongbuk, South Korea
[5] Univ Regensburg, Inst Pharm, D-93040 Regensburg, Germany
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 07期
关键词
D O I
10.1021/np000554f
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids related to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. Extending the alkyl chain at position 8 or 13 strongly influenced the cytotoxic activity, that is, relative lipophilicity as well as the size of the substituent affects cytotoxicity. The highest level of activity was observed in 8- or 13-hexyl-substituted derivatives of berberine. Structure - activity relationships are described.
引用
收藏
页码:896 / 898
页数:3
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