In vitro cytotoxicity of the protoberberine-type alkaloids

被引：95

作者：

Iwasa, K

Moriyasu, M

Yamori, T

Turuo, T

Lee, DU

Wiegrebe, W

机构：

[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Toyoshima Ku, Tokyo 1708455, Japan

[3] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130000, Japan

[4] Dongguk Univ, Coll Nat Sci, Dept Biochem, Kyongju 780714, Kyongbuk, South Korea

[5] Univ Regensburg, Inst Pharm, D-93040 Regensburg, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 07期

关键词：

D O I：

10.1021/np000554f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids related to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. Extending the alkyl chain at position 8 or 13 strongly influenced the cytotoxic activity, that is, relative lipophilicity as well as the size of the substituent affects cytotoxicity. The highest level of activity was observed in 8- or 13-hexyl-substituted derivatives of berberine. Structure - activity relationships are described.

引用

页码：896 / 898

页数：3

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