The best offense is a good defense

被引：15

作者：

Cramer, WA ^{[1
]}

Lindeberg, M ^{[1
]}

Taylor, R ^{[1
]}

机构：

[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1999年 / 6卷 / 04期

关键词：

D O I：

10.1038/7520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How does a cell employ a lethal toxin against neighboring cells of the same species, yet provide nearly perfect protection for itself? Two new structures offer insights into the nature of interactions between bacterial colicin toxins and the 'immunity' proteins that inhibit their activity.

引用

收藏

页码：295 / 297

页数：3

相关论文

共 8 条

[1] COLICINS - STRUCTURES, MODES OF ACTION, TRANSFER THROUGH MEMBRANES, AND EVOLUTION [J].

BRAUN, V ;

PILSL, H ;

GROSS, P .

ARCHIVES OF MICROBIOLOGY, 1994, 161 (03) :199-206

[2] The crystal structure of the immunity protein of colicin E7 suggests a possible colicin-interacting surface [J].

Chak, KF ;

Safo, MK ;

Ku, WY ;

Hsieh, SY ;

Yuan, HS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6437-6442

[3]

CRAMER WA, 1995, ANNU REV BIOPH BIOM, V24, P611, DOI 10.1146/annurev.biophys.24.1.611

[4] HIGHLY PURIFIED COLICIN-E3 CONTAINS IMMUNITY PROTEIN [J].

JAKES, KS ;

ZINDER, ND .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) :3380-3384

[5] Structural and mechanistic basis of immunity toward endonuclease colicins [J].

Kleanthous, C ;

Kühlmann, UC ;

Pommer, AJ ;

Ferguson, N ;

Radford, SE ;

Moore, GR ;

James, R ;

Hemmings, AM .

NATURE STRUCTURAL BIOLOGY, 1999, 6 (03) :243-252

[6] Immunity proteins and their specificity for endonuclease colicins: telling right from wrong in protein-protein recognition [J].

Kleanthous, C ;

Hemmings, AM ;

Moore, GR ;

James, R .

MOLECULAR MICROBIOLOGY, 1998, 28 (02) :227-233

[7] The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein [J].

Ko, TP ;

Liao, CC ;

Ku, WY ;

Chak, KF ;

Yuan, HS .

STRUCTURE WITH FOLDING & DESIGN, 1999, 7 (01) :91-102

[8] Three-dimensional solution structure and C-13 nuclear magnetic resonance assignments of the colicin E9 immunity protein Im9 [J].

Osborne, MJ ;

Breeze, AL ;

Lian, LY ;

Reilly, A ;

James, R ;

Kleanthous, C ;

Moore, GR .

BIOCHEMISTRY, 1996, 35 (29) :9505-9512