Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

被引：1456

作者：

Fleming, Fraser F. ^{[1
]}

Yao, Lihua ^{[1
]}

Ravikumar, P. C. ^{[1
]}

Funk, Lee ^{[2
]}

Shook, Brian C. ^{[3
]}

机构：

[1] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15282 USA

[2] Mylan Pharmaceut Inc, Morgantown, WV 26505 USA

[3] Johnson & Johnson Pharmaceut Res & Dev LLC, Spring House, PA 19477 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 22期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DIPEPTIDYL PEPTIDASE-4 INHIBITOR; REVERSE-TRANSCRIPTASE INHIBITORS; K-ATP OPENERS; ANTIHYPERTENSIVE AGENT CROMAKALIM; O-METHYLTRANSFERASE INHIBITORS; THROMBOXANE A(2) RECEPTOR; POTASSIUM-CHANNEL OPENERS; GROWTH-FACTOR RECEPTOR; STRUCTURE-BASED DESIGN; CEREBRAL-BLOOD-FLOW;

D O I：

10.1021/jm100762r

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：7902 / 7917

页数：16

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