Analysis of the novel cyclin-dependent kinase 4 and 6 inhibitor gene p18 in lymphoma and leukemia cell lines

被引：7

作者：

Siebert, R ^{[1
]}

Willers, CP ^{[1
]}

Fossa, A ^{[1
]}

Kloke, O ^{[1
]}

Nowrousian, MR ^{[1
]}

Seeber, S ^{[1
]}

Opalka, B ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH,SCH MED,W GERMAN CANC CTR ESSEN,DEPT MED ONCOL CANC RES,D-45122 ESSEN,GERMANY

来源：

LEUKEMIA RESEARCH | 1996年 / 20卷 / 02期

关键词：

cyclin-dependent kinase inhibitor; p18; lymphoma; leukemia;

D O I：

10.1016/0145-2126(95)00137-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The genes for the CDK4/6-inhibitors p16(INK4A)/MTS1 and p15(INK4B)/MTS2 frequently deleted in hematological malignancies. A new member of this family of CDK4/6 inhibitors is p18. In order to assess p18 growth-suppressor gene alterations in hematological neoplasms, we investigated 31 lymphoma and leukemia cell lines by PCR for both exons of this gene. No homozygous deletions were observed, Investigation of a new intragenic restriction fragment length polymorphism revealed no differences in allele distribution between the tumor cell lines and healthy volunteers. Our results suggest that homozygous deletion of the p18 gene does not play a major role in leukemogenesis or lymphomagenesis.

引用

页码：197 / 200

页数：4

共 8 条

[1]

DELMER A, 1995, LEUKEMIA, V9, P1240

[2]

GRANA X, 1995, ONCOGENE, V11, P211

[3] GROWTH SUPPRESSION BY P18, A P16(INK4/MTS1)-RELATED AND P14(INK4B/MTS2)-RELATED CDK6 INHIBITOR, CORRELATES WITH WILD-TYPE PRB FUNCTION [J].