Production of ouabain by rat adrenocortical cells

被引：16

作者：

Beck, M

Szalay, KS

Nagy, GM

Toth, M

deChatel, R

机构：

[1] SEMMELWEIS UNIV MED,SCH MED,DEPT ANAT 1,BUDAPEST,HUNGARY

[2] SEMMELWEIS UNIV MED,SCH MED,DEPT MED 1,BUDAPEST,HUNGARY

来源：

ENDOCRINE RESEARCH | 1996年 / 22卷 / 04期

关键词：

D O I：

10.1080/07435809609043784

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our aim was to identify which adrenocortical cells produce ouabain and how it is regulated in vitro. With the help of an ouabain radioimmunoassay developed in our laboratory, we found that ouabain is produced both by zona glomerulosa and fasciculata cells. Our results were confirmed by reverse-phase HPLC. ACTH increased ouabain production in both cell types. Angiotensin-II, as well as changes in the potassium concentration of the incubation medium, affected ouabain production only in the zona glomerulosa.

引用

页码：845 / 849

页数：5

共 6 条

[1]

HAMLYN JM, 1992, J HYPERTENS, V10, pS99

[2] IDENTIFICATION AND CHARACTERIZATION OF A OUABAIN-LIKE COMPOUND FROM HUMAN PLASMA [J].