Characterization of mouse GBP28 and its induction by exposure to cold

被引：36

作者：

Yoda, M

Nakano, Y

Tobe, T

Shioda, S

Choi-Miura, NH

Tomita, M

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Dept Physiol Chem, Shinagawa Ku, Tokyo 1428555, Japan

[2] Natl Inst Hlth Sci, Pharmaceut & Med Devices Evaluat Ctr, Tokyo 158, Japan

[3] Showa Univ, Sch Pharmaceut Sci, Dept Med Informat, Shinagawa Ku, Tokyo 1428555, Japan

[4] Showa Univ, Sch Med, Dept Anat, Tokyo 142, Japan

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2001年 / 25卷 / 01期

关键词：

adipocyte; GBP28; gelatin-binding; high-fat diet; fast; cold;

D O I：

10.1038/sj.ijo.0801482

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: To investigate whether the expression of the novel adipose tissue-specific protein GBP28 in adipose tissue and serum are altered in mice under a variety of conditions. DESIGN: Mice were fed a high-fat diet for 4 weeks, fasted for 48 h or exposed at 4 C. SUBJECTS: C578L/6J mouse, male, 4-6 weeks old. MEASUREMENTS: GBP28 mRNA, GBP28 protein, blood glucose, insulin and fad pad weight of the mice. RESULTS: We first confirmed that the mouse has GBP28 and its characteristics are the same as human GBP28. Serum concentration and mRNA levels of GBP28 significantly increased in the mice exposed to cold. CONCLUSION: GBP28 may play a role in homeostasis, regulating body temperature and basal metabolic rate in response to changing environmental conditions.

引用

页码：75 / 83

页数：9

共 21 条

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