Sheep with Scrapie and Mastitis Transmit Infectious Prions through the Milk

被引：43

作者：

Ligios, Ciriaco ^{[2
]}

Cancedda, Maria Giovanna ^{[2
]}

Carta, Antonello ^{[3
]}

Santucciu, Cinzia ^{[2
]}

Maestrale, Caterina ^{[2
]}

Demontis, Francesca ^{[2
]}

Saba, Mariangela ^{[2
]}

Patta, Cristiana ^{[2
]}

DeMartini, James C. ^{[4
]}

Aguzzi, Adriano ^{[1
]}

Sigurdson, Christina J. ^{[5
,6
]}

机构：

[1] Univ Spital Zurich, Inst Neuropathol, Dept Pathol, CH-8091 Zurich, Switzerland

[2] Ist Zooprofilatt Sperimentale Sardegna, Sassari, Italy

[3] AGRIS Sardinia, Res Unit Genet & Biotechnol, DIRPA, Olmedo, Italy

[4] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[5] Univ Calif San Diego, Dept Pathol, Sch Med, San Diego, CA 92093 USA

[6] Univ Calif Davis, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

CREUTZFELDT-JAKOB-DISEASE; OVINE LENTIVIRUS STRAINS; BLOOD-TRANSFUSION; PATHOGENESIS; MICE;

D O I：

10.1128/JVI.02022-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Prions are misfolded proteins that are infectious and naturally transmitted, causing a fatal neurological disease in humans and animals. Prion shedding routes have been shown to be modified by inflammation in excretory organs, such as the kidney. Here, we show that sheep with scrapie and lentiviral mastitis secrete prions into the milk and infect nearly 90% of naive suckling lambs. Thus, lentiviruses may enhance prion transmission, conceivably sustaining prion infections in flocks for generations. This study also indicates a risk of prion spread to sheep and potentially to other animals through dietary exposure to pooled sheep milk or milk products.

引用

页码：1136 / 1139

页数：4

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