How superoxide radical damages the cell

被引：88

作者：

Benov, L ^{[1
]}

机构：

[1] Kuwait Univ, Fac Med, Dept Biochem, Safat 13110, Kuwait

来源：

PROTOPLASMA | 2001年 / 217卷 / 1-3期

关键词：

oxidative stress; hydroxyl radical; superoxide dismutase;

D O I：

10.1007/BF01289410

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Superoxide is considered to be poorly reactive, and cell damage has been attributed to HO. generated via the Haber-Weiss reaction. The function of O-2(-). in this reaction is only to reduce Fe3+ to Fe2+. In vivo, however, superoxide could not out-compete cellular reductants such as glutathione, NADPH, and ascorbate, which makes the observed O-2(-) toxicity rather puzzling. Little attention has been paid to the idea that, irrespective of its poor chemical reactivity, superoxide might be capable of interacting directly with specific intracellular targets; and that even the Haber-Weiss reaction might be a consequence of such direct interactions. This paper summarizes latest data that support the concept of such a mechanism.

引用

页码：33 / 36

页数：4