Possible modes of action of the artemisinin-type compounds

被引：192

作者：

Olliaro, PL

Haynes, RK

Meunier, B

Yuthavong, Y

机构：

[1] UNDP, World Bank, WHO, Special Programme Res & Training Trop Dis, CH-1211 Geneva, Switzerland

[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

[3] CNRS, Chim Coordinat Lab, F-31077 Toulouse, France

[4] Natl Sci & Technol Dev Agcy, Thailand Grad Inst Sci & Technol, Bangkok, Thailand

来源：

TRENDS IN PARASITOLOGY | 2001年 / 17卷 / 03期

关键词：

D O I：

10.1016/S1471-4922(00)01838-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.

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页码：122 / 126

页数：5

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