Alkylating properties of synthetic trioxanes related to artemisinin

被引：23

作者：

Cazelles, J

Camuzat-Dedenis, B

Provot, O

Robert, A

Mayrargue, J

Meunier, B

机构：

[1] Univ Paris Sud, Fac Pharm, Chim Organ Lab, CNRS,UPRESA 8076, F-92296 Chatenay Malabry, France

[2] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 08期

关键词：

D O I：

10.1039/a909408c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and reactivity toward a haem model of trioxane derivatives bearing a 1,2-dioxacyclohexane cycle instead of a 1,2-dioxacycloheptane as in artemisinin, and lacking the lactone ring, are reported. The fact that a trioxane able to generate a C-centred radical (without alkylating ability toward a haem model) was devoid of toxicity against Plasmodium also suggests that the efficiency of antimalarial trioxanes is not due to an oxidant stress.

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页码：1265 / 1270

页数：6

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