Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp

被引：48

作者：

Murakami, Y ^{[1
]}

Kato, S ^{[1
]}

Nakajima, M ^{[1
]}

Matsuoka, M ^{[1
]}

Kawai, H ^{[1
]}

ShinYa, K ^{[1
]}

Seto, H ^{[1
]}

机构：

[1] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.839

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Formobactin, a new free radical scavenger, was isolated from the culture of Nocardia sp. strain ND20. The structure of formobactin was determined to be a member of the nocobactin group antibiotics. Formobactin inhibited lipid peroxidation in rat brain homogenate. Formobactin also showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.

引用

页码：839 / 845

页数：7

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