Modulation of multidrug resistance in tumor cells by taxinine derivatives

被引：33

作者：

Hosoyama, H ^{[1
]}

Shigemori, H

Tomida, A

Tsuruo, T

Kobayashi, J

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 03期

关键词：

biologically active compounds; glycopeptides/glycoproteins; molecular design; taxoids;

D O I：

10.1016/S0960-894X(99)00009-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Among a series of taxinine (1) and its designed derivatives (2 similar to 33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14 similar to 16, 22, and 30 similar to 32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：389 / 394

页数：6