A copper(II)-catalyzed aza-Friedel-Crafts reaction of N-(2-pyridyl)sulfonyl aldimines:: Synthesis of unsymmetrical diaryl amines and triaryl methanes

被引：216

作者：

Esquivias, J ^{[1
]}

Arrayás, RG ^{[1
]}

Carretero, JC ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Organ, E-28049 Madrid, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 04期

关键词：

amines; copper; homogeneous catalysis; nitrogen heterocycles; Schiff bases;

D O I：

10.1002/anie.200503305

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The choice of the (2-pyridyl)sulfonyl moiety as an N-protecting group and Cu(OTf)2/(±)-binap as catalyst system lead to a highly efficient aza-Friedel-Crafts reaction of electron-rich arenes (Ar2-H) and heteroarenes with N-sulfonyl imines. This protocol is also amenable to the synthesis of unsymmetrical triaryl methanes through a second electrophilic aromatic substitution with a different electron-rich arene (Ar3-H; see scheme). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：629 / 633

页数：5

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