IL-7Rα and multiple sclerosis risk

被引：10

作者：

Harley, John B.

机构：

[1] Oklahoma Med Res Fdn, Arthrit & Immunol Program, Oklahoma City, OK 73104 USA

[2] US Dept Vet Affairs, Med Ctr, Oklahoma City, OK 73104 USA

来源：

NATURE GENETICS | 2007年 / 39卷 / 09期

关键词：

D O I：

10.1038/ng0907-1053

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The discovery of genetic risk factors for multiple sclerosis has proven difficult. IL- 7R alpha, encoded by IL7R, is a pleiomorphic cytokine receptor now implicated in the pathogenesis of multiple sclerosis in independently replicated genetic association studies.

引用

页码：1053 / 1054

页数：2

共 14 条

[1] Replicating genotype-phenotype associations [J].

Chanock, Stephen J. ;

Manolio, Teri ;

Boehnke, Michael ;

Boerwinkle, Eric ;

Hunter, David J. ;

Thomas, Gilles ;

Hirschhorn, Joel N. ;

Abecasis, Goncalo ;

Altshuler, David ;

Bailey-Wilson, Joan E. ;

Brooks, Lisa D. ;

Cardon, Lon R. ;

Daly, Mark ;

Donnelly, Peter ;

Fraumeni, Joseph F., Jr. ;

Freimer, Nelson B. ;

Gerhard, Daniela S. ;

Gunter, Chris ;

Guttmacher, Alan E. ;

Guyer, Mark S. ;

Harris, Emily L. ;

Hoh, Josephine ;

Hoover, Robert ;

Kong, C. Augustine ;

Merikangas, Kathleen R. ;

Morton, Cynthia C. ;

Palmer, Lyle J. ;

Phimister, Elizabeth G. ;

Rice, John P. ;

Roberts, Jerry ;

Rotimi, Charles ;

Tucker, Margaret A. ;

Vogan, Kyle J. ;

Wacholder, Sholom ;

Wijsman, Ellen M. ;

Winn, Deborah M. ;

Collins, Francis S. .

NATURE, 2007, 447 (7145) :655-660

[2] A meta-analysis of whole genome linkage screens in multiple sclerosis [J].

JOURNAL OF NEUROIMMUNOLOGY, 2003, 143 (1-2) :39-46

[3] Power and sample size calculations for case-control genetic association tests when errors are present: Application to single nucleotide polymorphisms [J].

Gordon, D ;

Finch, SJ ;

Nothnagel, M ;

Ott, J .

HUMAN HEREDITY, 2002, 54 (01) :22-33

[4]

Gordon D, 2003, Pac Symp Biocomput, P490

[5] Interleukin 7 receptor a chain (IL7R) shows allelic and functional association with multiple sclerosis [J].

Gregory, Simon G. ;

Schmidt, Silke ;

Seth, Puneet ;

Oksenberg, Jorge R. ;

Hart, John ;

Prokop, Angela ;

Caillier, Stacy J. ;

Ban, Maria ;

Goris, An ;

Barcellos, Lisa F. ;

Lincoln, Robin ;

McCauley, Jacob L. ;

Sawcer, Stephen J. ;

Compston, D. A. S. ;

Dubois, Benedicte ;

Hauser, Stephen L. ;

Garcia-Blanco, Mariano A. ;

Pericak-Vance, Margaret A. ;

Haines, Jonathan L. .

NATURE GENETICS, 2007, 39 (09) :1083-1091

[6] Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage [J].

Hauser, MA ;

Li, YJ ;

Takeuchi, S ;

Walters, R ;

Noureddine, M ;

Maready, M ;

Darden, T ;

Hulette, C ;

Martin, E ;

Hauser, E ;

Xu, H ;

Schmechel, D ;

Stenger, JE ;

Dietrich, F ;

Vance, J .

HUMAN MOLECULAR GENETICS, 2003, 12 (06) :671-677

[7]

*INT MULT SCLER GE, 2007, NEW ENGL J MED, DOI DOI 10.1056/NEJMOA073403

[8] Complement factor H polymorphism in age-related macular degeneration [J].

Klein, RJ ;

Zeiss, C ;

Chew, EY ;

Tsai, JY ;

Sackler, RS ;

Haynes, C ;

Henning, AK ;

SanGiovanni, JP ;

Mane, SM ;

Mayne, ST ;

Bracken, MB ;

Ferris, FL ;

Ott, J ;

Barnstable, C ;

Hoh, J .

SCIENCE, 2005, 308 (5720) :385-389

[9] Variation in interleukin 7 receptor a chain (IL7R) influences risk of multiple sclerosis [J].

Lundmark, Frida ;

Duvefelt, Kristina ;

Iacobaeus, Ellen ;

Kockum, Ingrid ;

Wallstroem, Erik ;

Khademi, Mohsen ;

Oturai, Annette ;

Ryder, Lars P. ;

Saarela, Janna ;

Harbo, Hanne F. ;

Celius, Elisabeth G. ;

Salter, Hugh ;

Olsson, Tomas ;

Hillert, Jan .

NATURE GENETICS, 2007, 39 (09) :1108-1113

[10] Genomic convergence to identify Parkinson disease: SAGE analysis candidate genes for of the substantia nigra [J].

Noureddine, MA ;

Li, YJ ;

van der Walt, JM ;

Walters, R ;

Jewett, RM ;

Xu, H ;

Wang, TY ;

Walter, JW ;

Scott, BL ;

Hulette, C ;

Schmechel, D ;

Stenger, JE ;

Dietrich, F ;

Vance, JM ;

Hauser, MA .

MOVEMENT DISORDERS, 2005, 20 (10) :1299-1309

← 1 2 →