Polarization of B effector cells in Sjogren's syndrome

被引：33

作者：

Daridon, Capucine

Guerrier, Thomas

Devauchelle, Valerie

Saraux, Alain

Pers, Jacques-Olivier

Youinou, Pierre

机构：

[1] Brest Univ Med Sch Hosp, Immunol Lab, F-29609 Brest, France

[2] Brest Univ Med Sch Hosp, Rheumatol Unit, F-29609 Brest, France

来源：

AUTOIMMUNITY REVIEWS | 2007年 / 6卷 / 07期

关键词：

cytokine; Sjogren's syndrome; B-lymphocyte;

D O I：

10.1016/j.autrev.2007.01.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Analysis of salivary glands of patients with primary Sjogren's syndrome has yielded, conflicting results with respect to T helper (Th)1/Th2 polarization. This balance might parallel the progress of the local lesions. B-cells are now taking center stage in this disease. They can also be primed to differentiate into two cytokine-production pathways, dubbed B effector (Be) 1 and Be2 cells. This is discussed in the light of our recent finding that Be I accompany Th1, while Be2 accompany in the tissue lesions. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：427 / 431

页数：5