Novel bromotyrosine derivatives that inhibit growth of the fish pathogenic bacterium Aeromonas hydrophila, from a marine sponge Hexadella sp.

被引：16

作者：

Matsunaga, S

Kobayashi, H

van Soest, RWM

Fusetani, N ^{[1
]}

机构：

[1] Univ Tokyo, Lab Aquat Nat Prod Chem, Grad Sch Agr Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Univ Amsterdam, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 05期

关键词：

D O I：

10.1021/jo048203j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new bromotyrosine derivatives, 11-N-methylmoloka'iamine (1), 11-N-eyano-11-N-methylmoloka'iamine (2), and kuchinoenamine (3), were isolated as antibacterial constituents from a marine sponge Hexadella sp. Their structures were elucidated on the basis of spectral and chemical methods. They exhibited moderate antibacterial activity against the fish pathogenic bacterium Aeromonas hydrophila.

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页码：1893 / 1896

页数：4

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