Development of computational models for enzymes, transporters, channels, and receptors relevant to ADME/Tox

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[72] Identification of the cyclosporin-binding site in P-glycoprotein [J]. BIOCHEMISTRY, 1998, 37 (51) : 18110 - 18118

[73] Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) : 10594 - 10599

[74] Bioactive diversity and screening library selection via affinity fingerprinting [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1998, 38 (06): : 1192 - 1203

[75] cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450 [J]. MOLECULAR PHARMACOLOGY, 2001, 59 (02) : 386 - 392

[76] Analysis of four residues within substrate recognition site 4 of human cytochrome p450 3A4:: Role in steroid hydroxylase activity and α-naphthoflavone stimulation [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 350 (02) : 223 - 232

[77] Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity [J]. BIOCHEMISTRY, 2001, 40 (34) : 10150 - 10160

[78] Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (36) : 23211 - 23218

[79] Dresser MJ, 2001, J PHARM SCI, V90, P397, DOI 10.1002/1520-6017(200104)90:4<397::AID-JPS1000>3.0.CO

[80] 2-D

[71] A PREDICTIVE SUBSTRATE MODEL FOR RAT GLUTATHIONE-S-TRANSFERASE-4-4 [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1995, 8 (05) : 649 - 658

[72] Identification of the cyclosporin-binding site in P-glycoprotein [J]. BIOCHEMISTRY, 1998, 37 (51) : 18110 - 18118

[73] Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) : 10594 - 10599

[74] Bioactive diversity and screening library selection via affinity fingerprinting [J]. JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1998, 38 (06): : 1192 - 1203

[75] cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450 [J]. MOLECULAR PHARMACOLOGY, 2001, 59 (02) : 386 - 392

[76] Analysis of four residues within substrate recognition site 4 of human cytochrome p450 3A4:: Role in steroid hydroxylase activity and α-naphthoflavone stimulation [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 350 (02) : 223 - 232

[77] Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity [J]. BIOCHEMISTRY, 2001, 40 (34) : 10150 - 10160

[78] Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (36) : 23211 - 23218

[79] Dresser MJ, 2001, J PHARM SCI, V90, P397, DOI 10.1002/1520-6017(200104)90:4<397::AID-JPS1000>3.0.CO

[80] 2-D