Appearance of angiotensin II expression in non-basal epithelial cells is an early feature of malignant change in human prostate

被引：12

作者：

Louis, Simon N. ^{[1
]}

Wang, Lin ^{[1
]}

Chow, Laurie ^{[1
]}

Rezmann, Linda A. ^{[1
]}

Imamura, Keisaku ^{[1
]}

MacGregor, Duncan P. ^{[2
]}

Casely, David

Catt, Kevin J. ^{[3
]}

Frauman, Albert G. ^{[1
]}

Louis, William J. ^{[1
]}

机构：

[1] Univ Melbourne, Clin Pharmacol & Therapeut Unit, Dept Med, Heidelberg, Vic 3084, Australia

[2] Dept Anat Pathol, Heidelberg, Vic 3084, Australia

[3] NICHD, Endocrinol & Reprod Res Branch, NIH, Bethesda, MD 20892 USA

来源：

CANCER DETECTION AND PREVENTION | 2007年 / 31卷 / 05期

关键词：

angiotensin II; prostate cancer; benign prostatic hyperplasia; prostatic intraepithelial neoplasia; immunohistochemistry;

D O I：

10.1016/j.cdp.2007.08.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite increasing interest in the renin-angiotensin system in cancer, little is known about angiotensin II (Ang II) expression in human prostate tumors. Methods: Using immunohistochemistry, we examined Ang II expression in prostate cancer (Gleason grades 2-5), benign prostatic hyperplasia (BPH), and high-grade prostatic intraepithelial neoplasia (HGPIN). Results: Ang II was present in proliferating neoplastic cells in HGPIN, in malignant cells in all grades of prostate cancer examined, in basal but not luminal epithelial cells in BPH, and in the cytoplasm of LNCaP, DU145, and PO prostate cancer cells. Conclusions: The data establishes the presence of Ang II in pre-malignant and malignant prostate cells, suggests Ang II staining in non-basal epithelial cells is an early sign of malignant change, and supports suggestions that HGPIN and malignant prostate cells both arise from transformed basal cells. Using immunohistochemistry we examined Ang II expression in proliferative disorders of the prostate and concluded that Ang II staining in non-basal epithelial cells is evidence of early malignant change. (c) 2007 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.

引用

页码：391 / 395

页数：5

共 26 条

[1] Old antihypertensives as novel antineoplastics:: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists [J].

Abali, H ;

Güllü, IH ;

Engin, H ;

Haznedaroglu, IC ;

Erman, M ;

Tekuzman, G .

MEDICAL HYPOTHESES, 2002, 59 (03) :344-348

[2]

[Anonymous], 2000, TUMORS PROSTATE GLAN

[3] THE PROLIFERATIVE FUNCTION OF BASAL CELLS IN THE NORMAL AND HYPERPLASTIC HUMAN PROSTATE [J].

BONKHOFF, H ;

STEIN, U ;

REMBERGER, K .

PROSTATE, 1994, 24 (03) :114-118

[4]

Bonkhoff H, 1996, EUR UROL, V30, P201

[5] High-grade prostatic intraepithelial neoplasia [J].

Bostwick, DG ;

Qian, JQ .

MODERN PATHOLOGY, 2004, 17 (03) :360-379

[6]

Cheng Liang, 2004, Clin Prostate Cancer, V3, P26

[7]

de Gasparo M, 2000, PHARMACOL REV, V52, P415

[8] Evidence for activation of the renin-angiotensin system in the human prostate:: increased angiotensin II and reduced AT1 receptor expression in prostatic hyperplasia [J].

Dinh, DT ;

Frauman, AG ;

Somers, GR ;

Ohishi, M ;

Zhou, JL ;

Casley, DJ ;

Johnston, CI ;

Fabiani, ME .

JOURNAL OF PATHOLOGY, 2002, 196 (02) :213-219

[9] Identification, distribution, and expression of angiotensin II receptors in the normal human prostate and benign prostatic hyperplasia [J].

Dinh, DT ;

Frauman, AG ;

Sourial, M ;

Casley, DJ ;

Johnston, CI ;

Fabiani, ME .

ENDOCRINOLOGY, 2001, 142 (03) :1349-1356

[10]

GLEASON DONALD F., 1966, CANCER CHEMO THERAP REP, V50, P125

← 1 2 3 →