A Novel Approach for Studying Histone H1 Function in Vivo

被引：2

作者：

Siriaco, Giorgia ^{[1
]}

Deuring, Renate ^{[1
]}

Mawla, Gina D. ^{[1
]}

Tamkun, John W. ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

来源：

GENETICS | 2015年 / 200卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Drosophila; histone H1; chromatin; gene expression; NUCLEOSOME REPEAT LENGTH; LINKER HISTONE; DROSOPHILA-MELANOGASTER; GENE-EXPRESSION; POSTTRANSLATIONAL MODIFICATIONS; CHROMATIN-STRUCTURE; HETEROCHROMATIN; STOICHIOMETRY; PATTERN; CELLS;

D O I：

10.1534/genetics.114.170514

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

In this report, we investigate the mechanisms that regulate Drosophila histone H1 expression and its association with chromatin in vivo. We show that histone H1 is subject to negative autoregulation and exploit this result to examine the effects of mutations of the main phosphorylation site of histone H1.

引用

页码：29 / 33

页数：5

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