Assessment of risk of insect-resistant transgenic crops to nontarget arthropods

被引：339

作者：

Romeis, Joerg ^{[1
]}

Bartsch, Detlef ^{[2
]}

Bigler, Franz ^{[1
]}

Candolfi, Marco P. ^{[3
]}

Gielkens, Marco M. C. ^{[4
]}

Hartley, Susan E. ^{[5
]}

Hellmich, Richard L. ^{[6
,7
]}

Huesing, Joseph E. ^{[8
]}

Jepson, Paul C. ^{[9
,10
]}

Layton, Raymond ^{[11
]}

Quemada, Hector ^{[12
]}

Raybould, Alan ^{[13
]}

Rose, Robyn I. ^{[14
]}

Schiemann, Joachim ^{[15
]}

Sears, Mark K. ^{[16
]}

Shelton, Anthony M. ^{[17
]}

Sweet, Jeremy ^{[18
]}

Vaituzis, Zigfridas ^{[19
]}

Wolt, Jeffrey D. ^{[20
,21
]}

机构：

[1] Agroscope Reckenholz Tanikon Res Stn ART, CH-8046 Zurich, Switzerland

[2] Fed Off Consumer Protect & Food Safety BVL, D-10117 Berlin, Germany

[3] RCC Labs India Private Ltd, Hyderabad 500078, Andhra Pradesh, India

[4] Natl Inst Publ Hlth & Environm, Expertise Ctr Substances, NL-3720 BA Bilthoven, Netherlands

[5] Univ Sussex, Dept Biol & Environm Sci, Brighton BN1 9QG, E Sussex, England

[6] Iowa State Univ, Dept Entomol, Ames, IA 50011 USA

[7] Iowa State Univ, USDA ARS, Corn Insects & Crop Genet Res Unit, Ames, IA 50011 USA

[8] Monsanto Co, St Louis, MO 63167 USA

[9] Oregon State Univ, Integrated Plant Protect Ctr, Corvallis, OR 97331 USA

[10] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA

[11] DuPont Crop Genet, Johnston, IA 50131 USA

[12] Calvin Coll, Dept Biol, Program Biosafety Syst, Grand Rapids, MI 49546 USA

[13] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

[14] USDA, APHIS Biotechnol Regulatory Serv, Riverdale, MD 20737 USA

[15] Julius Kuehn Inst, Fed Res Ctr Cultivated Plants, Inst Biosafety Genetically Modified Palnts, D-38104 Braunschweig, Germany

[16] Univ Guelph, Dept Environm Biol, Guelph, ON N1G 2W1, Canada

[17] Cornell Univ, New York State Agr Expt Stn, Dept Entomol, Geneva, NY 14456 USA

[18] Green Willingham, Cambridge CB4 5JA, England

[19] US EPA, Biopesticides & Pollut Prevent Div, Washington, DC 20460 USA

[20] Iowa State Univ, Dept Agron, Ames, IA 50011 USA

[21] Iowa State Univ, Biosafety Inst Genetically Modified Agr Prod, Ames, IA 50011 USA

来源：

NATURE BIOTECHNOLOGY | 2008年 / 26卷 / 02期

关键词：

D O I：

10.1038/nbt1381

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An international initiative is developing a scientifically rigorous approach to evaluate the potential risks to nontarget arthropods (NTAs) posed by insect-resistant, genetically modified (IRGM) crops. It adapts the tiered approach to risk assessment that is used internationally within regulatory toxicology and environmental sciences. The approach focuses on the formulation and testing of clearly stated risk hypotheses, making maximum use of available data and using formal decision guidelines to progress between testing stages (or tiers). It is intended to provide guidance to regulatory agencies that are currently developing their own NTA risk assessment guidelines for IRGM crops and to help harmonize regulatory requirements between different countries and different regions of the world.

引用

页码：203 / 208

页数：6

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