Non-traditionally derived CTL epitopes: exceptions that prove the rules?

被引:56
作者
Mayrand, SM [1 ]
Green, WR
机构
[1] Dartmouth Med Sch, Dept Microbiol, Hanover, NH 03756 USA
[2] Dartmouth Med Sch, Norris Cotton Canc Ctr, Hanover, NH 03756 USA
来源
IMMUNOLOGY TODAY | 1998年 / 19卷 / 12期
关键词
D O I
10.1016/S0167-5699(98)01342-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent data indicate that cytotoxic T lymphocyte (CTL) epitopes in viral, tumor and model systems are encoded by non-primary open reading frame (ORF) sequences, as well as other non-traditional sources. Here, Shawn-Marie Mayrand and William Green review these findings and discuss whether these non-traditionally derived CTL epitopes influence the shaping of the T-cell repertoire and immune regulation.
引用
收藏
页码:551 / 556
页数:6
相关论文
共 37 条
[1]   T-CELL-RECOGNIZED ANTIGENIC PEPTIDES DERIVED FROM THE CELLULAR GENOME ARE NOT PROTEIN-DEGRADATION PRODUCTS BUT CAN BE GENERATED DIRECTLY BY TRANSCRIPTION AND TRANSLATION OF SHORT SUBGENIC REGIONS - A HYPOTHESIS [J].
BOON, T ;
VANPEL, A .
IMMUNOGENETICS, 1989, 29 (02) :75-79
[2]  
BOON T, 1989, COLD SH Q B, V54, P587
[3]   MINIMAL REQUIREMENTS FOR PEPTIDE MEDIATED ACTIVATION OF CD8(+) CTL [J].
BROWER, RC ;
ENGLAND, R ;
TAKESHITA, T ;
KOZLOWSKI, S ;
MARGULIES, DH ;
BERZOFSKY, JA ;
DELISI, C .
MOLECULAR IMMUNOLOGY, 1994, 31 (16) :1285-1293
[4]   Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames [J].
Bullock, TNJ ;
Eisenlohr, LC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (04) :1319-1329
[5]   Initiation codon scanthrough versus termination codon readthrough demonstrates strong potential for major histocompatibility complex class I-restricted cryptic epitope expression [J].
Bullock, TNJ ;
Patterson, AE ;
Franlin, LL ;
Notidis, E ;
Eisenlohr, LC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (07) :1051-1058
[6]   T-CELL RECEPTOR-MHC CLASS-I PEPTIDE INTERACTIONS - AFFINITY, KINETICS, AND SPECIFICITY [J].
CORR, M ;
SLANETZ, AE ;
BOYD, LF ;
JELONEK, MT ;
KHILKO, S ;
ALRAMADI, BK ;
KIM, YS ;
MAHER, SE ;
BOTHWELL, ALM ;
MARGULIES, DH .
SCIENCE, 1994, 265 (5174) :946-949
[7]   A MUTATED INTRON SEQUENCE CODES FOR AN ANTIGENIC PEPTIDE RECOGNIZED BY CYTOLYTIC T-LYMPHOCYTES ON A HUMAN-MELANOMA [J].
COULIE, PG ;
LEHMANN, F ;
LETHE, B ;
HERMAN, J ;
LURQUIN, C ;
ANDRAWISS, M ;
BOON, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7976-7980
[8]   T-CELL RECEPTORS - SERIAL ENGAGEMENT PROPOSED [J].
DAVIS, MM .
NATURE, 1995, 375 (6527) :104-104
[9]   THE MINIMAL NUMBER OF CLASS-II MHC ANTIGEN COMPLEXES NEEDED FOR T-CELL ACTIVATION [J].
DEMOTZ, S ;
GREY, HM ;
SETTE, A .
SCIENCE, 1990, 249 (4972) :1028-1030
[10]   Recognition of out-of-frame major histocompatibility complex class I-restricted epitopes in vivo [J].
Elliott, T ;
Bodmer, H ;
Townsend, A .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (05) :1175-1179