Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues

被引：110

作者：

Ovsianikov, Aleksandr ^{[1
]}

Deiwick, Andrea ^{[1
]}

Van Vlierberghe, Sandra ^{[2
]}

Pflaum, Michael ^{[3
]}

Wilhelmi, Mathias ^{[3
]}

Dubruel, Peter ^{[2
]}

Chichkov, Boris ^{[1
]}

机构：

[1] Laser Zentrum Hannover EV, Dept Nanotechnol, Hollerithallee 8, D-30419 Hannover, Germany

[2] Univ Ghent, Polymer Chem & Biomat Res Grp, B-9000 Ghent, Belgium

[3] Hannover Med Sch, Dept Cardiac Thora Transplantat & Vasc Surg, D-30625 Hannover, Germany

来源：

MATERIALS | 2011年 / 4卷 / 01期

关键词：

scaffolds; computer-aided design; laser fabrication; two-photon polymerization; gelatin; tissue engineering; biodegradation; stem cells; adipose tissue; HYDROGELS; DESIGN;

D O I：

10.3390/ma4010288

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the present work, the two-photon polymerization (2PP) technique was applied to develop precisely defined biodegradable 3D tissue engineering scaffolds. The scaffolds were fabricated via photopolymerization of gelatin modified with methacrylamide moieties. The results indicate that the gelatin derivative (GelMod) preserves its enzymatic degradation capability after photopolymerization. In addition, the developed scaffolds using 2PP support primary adipose-derived stem cell (ASC) adhesion, proliferation and differentiation into the anticipated lineage.

引用

页码：288 / 299

页数：12

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