Membrane trafficking of G protein-coupled receptors

被引：160

作者：

Tan, CM ^{[1
]}

Brady, AE ^{[1
]}

Nickols, HH ^{[1
]}

Wang, Q ^{[1
]}

Limbird, LE ^{[1
]}

机构：

[1] Vanderbilt Univ, Ctr Med, Dept Pharmacol, Nashville, TN 37232 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2004年 / 44卷

关键词：

protein-protein interactions; agonist-elicited endocytosis;

D O I：

10.1146/annurev.pharmtox.44.101802.121558

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

G protein-coupled receptors (GPCRs) modulate diverse physiological and behavioral signaling pathways by virtue of changes in receptor activation and inactivation states. Functional changes in receptor properties include dynamic interactions with regulatory molecules and trafficking to various cellular compartments at various stages of the life cycle of a GPCR. This review focuses on trafficking of GPCRs to the cell surface, stabilization there, and agonist-regulated turnover. GPCR interactions with a variety of newly revealed partners also are reviewed with the intention of provoking further analysis of the relevance of these interactions in GPCR trafficking, signaling, or both. The disease consequences of mislocalization. of GPCRs also are described.

引用

页码：559 / 609

页数：51

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