P1B-ATPases -: an ancient family of transition metal pumps with diverse functions in plants

被引：304

作者：

Williams, LE ^{[1
]}

Mills, RF ^{[1
]}

机构：

[1] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

TRENDS IN PLANT SCIENCE | 2005年 / 10卷 / 10期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tplants.2005.08.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

P-1B-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of organisms, including plants. Structurally they are distinct from other P-types, possessing eight transmembrane helices, a CPx/SPC motif in transmembrane domain six, and putative transition metal-binding domains at the N- and/or C-termini. Arabidopsis has eight P-1B-ATPases (AtHMA1-AtHMA8), which differ in their structure, function and regulation. They perform a variety of important physiological tasks relating to transition metal transport and homeostasis. The crucial roles of plant P-1B-ATPases in micronutrient nutrition, delivery of essential metals to target proteins, and toxic metal detoxification are discussed.

引用

页码：491 / 502

页数：12

共 60 条

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