Genetic control of lung development

被引:40
作者
Roth-Kleiner, M
Post, M
机构
[1] Univ Toronto, Hosp Sick Children, Program Lung Biol,Res Inst, Dept Lab Med, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Hosp Sick Children, Program Lung Biol,Res Inst, Dept Pediat, Toronto, ON M5G 1X8, Canada
来源
BIOLOGY OF THE NEONATE | 2003年 / 84卷 / 01期
关键词
lung; developmental biology; growth factors; transcription factors; adhesion molecules; extracellular matrix proteins; elastin; pulmonary surfactants;
D O I
10.1159/000071009
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Lung organogenesis is a developmental process that starts in human 4-5 weeks after conception and continues during the first years of life. It can be subdivided in six different stages: embryonic, pseudoglandular, canalicular, saccular and alveolar stage and stage of vascular maturation. In each of these periods, multiple molecules like transcription factors, growth factors and other signaling molecules and their respective receptors control and coordinate the course of events by a distinct expression and activity over space and time. Epithelial-mesenchymal interactions, physiological mechanical forces as well as humoral factors modulate some of these expression patterns. Although numerous key players and their mode of action have been discovered, many wait to be unveiled. Herein, we will summarize the current concepts of lung development with special consideration of the genetic control of lung genesis, growth and maturation. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码:83 / 88
页数:6
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