Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing

被引：30

作者：

Astakhova, Irina V. ^{[1
]}

Lindegaard, Dorthe ^{[1
]}

Korshun, Vladimir A. ^{[2
]}

Wengel, Jesper ^{[1
]}

机构：

[1] Univ So Denmark, Dept Chem & Phys, Nucle Acid Ctr, DK-5230 Odense M, Denmark

[2] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 44期

基金：

新加坡国家研究基金会;

关键词：

NUCLEIC-ACID; LNA;

D O I：

10.1039/c0cc03026k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functionalisation of 2'-amino-LNA oligonucleotides with 1-, 2- and 4-(phenylethynyl)pyrene fluorophores via a carbonyl linker (PEPyc) resulted in efficient interstrand communication systems in nucleic acid duplexes, providing effective tools for stabilization of nanostructures and fluorescence monitoring of DNA self-assembly.

引用

页码：8362 / 8364

页数：3

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