Polyphenols and Human Health: A Prospectus

被引：299

作者：

Visioli, Francesco ^{[1
]}

Alarcon-de-la-Lastra, Catalina ^{[2
]}

Andres-Lacueva, Cristina ^{[3
]}

Aviram, Michael ^{[4
]}

Calhau, Conceicao ^{[5
]}

Cassano, Alfredo ^{[6
]}

D'Archivio, Massimo ^{[7
]}

Faria, Ana ^{[5
]}

Fave, Gaelle ^{[8
]}

Fogliano, Vincenzo ^{[9
]}

Llorach, Rafael ^{[3
]}

Vitaglione, Paola ^{[9
]}

Zoratti, Mario ^{[10
]}

Edeas, Marvin ^{[11
]}

机构：

[1] IMDEA Food, Campus Cantoblanco,Celle Faraday 7, Madrid 28049, Spain

[2] Univ Seville, Fac Farm, Seville, Spain

[3] Univ Barcelona, Nutr & Food Sci Dept, E-08007 Barcelona, Spain

[4] Rambam Med Ctr, Haifa, Israel

[5] Univ Porto, Dept Biochem, Oporto, Portugal

[6] Univ Calabria, ITM CNR, I-87036 Arcavacata Di Rende, Italy

[7] Ist Super Sanita, I-00161 Rome, Italy

[8] Newcastle Univ, Inst Ageing & Hlth, Human Nutr Res Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[9] Univ Naples Federico II, Dept Food Sci, I-80138 Naples, Italy

[10] CNR, Inst Neurosci, Padua, Italy

[11] Soc Francaise Antioxydants, Paris, France

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2011年 / 51卷 / 06期

关键词：

polyphenols; metabolomics; cardiovascular disease; antioxidants; cancer; bioavailability; TARGETED PLASTOQUINONE DERIVATIVES; MITOCHONDRIAL PERMEABILITY TRANSITION; POMEGRANATE JUICE CONSUMPTION; PLASMA ANTIOXIDANT CAPACITY; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; IN-VITRO; INTERRUPT EXECUTION; RESVERATROL METABOLITES; OXIDATIVE STRESS;

D O I：

10.1080/10408391003698677

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The lay press often heralds polyphenols as panacea for all sorts of diseases. The rationale is that their antioxidant activity would prevent free radical damage to macromolecules. However, basic and clinical science is showing that the reality is much more complex than this and that several issues, notably content in foodstuff, bioavailability, or in vivo antioxidant activity are yet to be resolved. We summarize the recent findings concerning the effects of polyphenols on human health, analyze the current limitations at pitfalls, and propose future directions for research.

引用

页码：524 / 546

页数：23

共 202 条

[1]

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells [J].

Agapova, L. S. ;

Chernyak, B. V. ;

Domnina, L. V. ;

Dugina, V. B. ;

Efimenko, A. Yu. ;

Fetisova, E. K. ;

Ivanova, O. Yu. ;

Kalinina, N. I. ;

Khromova, N. V. ;

Kopnin, B. P. ;

Kopnin, P. B. ;

Korotetskaya, M. V. ;

Lichinitser, M. R. ;

Lukashev, A. L. ;

Pletjushkina, O. Yu. ;

Popova, E. N. ;

Skulachev, M. V. ;

Shagieva, G. S. ;

Stepanova, E. V. ;

Titova, E. V. ;

Tkachuk, V. A. ;

Vasiliev, J. M. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1300-1316

[2]

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases [J].

Aggarwal, Bharat B. ;

Harikumar, Kuzhuvelil B. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (01) :40-59

[3]

AGRAWAL R, 2009, PHARM RES

[4]

ALARCON DC, 2008, MOL NUTR FOOD RES, V52, P985

[5]

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers [J].

Almeida, Luis ;

Vaz-da-Silva, Manuel ;

Falcao, Amilcar ;

Soares, Eva ;

Costa, Raquel ;

Loureiro, Ana I. ;

Fernandes-Lopes, Carlos ;

Rocha, Jose-Francisco ;

Nunes, Teresa ;

Wright, Lyndon ;

Soares-da-Silva, Patricio .

MOLECULAR NUTRITION & FOOD RESEARCH, 2009, 53 :S7-S15

[6]

Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo [J].

Amara, Catherine E. ;

Shankland, Eric G. ;

Jubrias, Sharon A. ;

Marcinek, David J. ;

Kushmerick, Martin J. ;

Conley, Kevin E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :1057-1062

[7]

Bioavailability of curcumin: Problems and promises [J].

Anand, Preetha ;

Kunnumakkara, Ajaikumar B. ;

Newman, Robert A. ;

Aggarwal, Bharat B. .

MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818

[8]

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence [J].

Anisimov, V. N. ;

Bakeeva, L. E. ;

Egormin, P. A. ;

Filenko, O. F. ;

Isakova, E. F. ;

Manskikh, V. N. ;

Mikhelson, V. M. ;

Panteleeva, A. A. ;

Pasyukova, E. G. ;

Pilipenko, D. I. ;

Piskunova, T. S. ;

Popovich, I. G. ;

Roshchina, N. V. ;

Rybina, O. Yu. ;

Saprunova, V. B. ;

Samoylova, T. A. ;

Semenchenko, A. V. ;

Skulachev, M. V. ;

Spivak, I. M. ;

Tsybul'ko, E. A. ;

Tyndyk, M. L. ;

Vyssokikh, M. Yu. ;

Yurova, M. N. ;

Zabezhinsky, M. A. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1329-1342

[9]

[Anonymous], DIET GUID AM

[10]

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies [J].

Antonenko, Y. N. ;

Avetisyan, A. V. ;

Bakeeva, L. E. ;

Chernyak, B. V. ;

Chertkov, V. A. ;

Domnina, L. V. ;

Ivanova, O. Yu. ;

Izyumov, D. S. ;

Khailova, L. S. ;

Klishin, S. S. ;

Korshunova, G. A. ;

Lyamzaev, K. G. ;

Muntyan, M. S. ;

Nepryakhina, O. K. ;

Pashkovskaya, A. A. ;

Pletjushkina, O. Yu. ;

Pustovidko, A. V. ;

Roginsky, V. A. ;

Rokitskaya, T. I. ;

Ruuge, E. K. ;

Saprunova, V. B. ;

Severina, I. I. ;

Simonyan, R. A. ;

Skulachev, I. V. ;

Skulachev, M. V. ;

Sumbatyan, N. V. ;

Sviryaeva, I. V. ;

Tashlitsky, V. N. ;

Vassiliev, J. M. ;

Vyssokikh, M. Yu. ;

Yaguzhinsky, L. S. ;

Zamyatnin, A. A., Jr. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1273-1287

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