Mediators of the inflammatory response to joint replacement devices

被引:153
作者
Cobelli, Neil [3 ]
Scharf, Brian [1 ]
Crisi, Giovanna M. [4 ]
Hardin, John [2 ]
Santambrogio, Laura [1 ]
机构
[1] Albert Einstein Coll Med, Dept Pathol, New York, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Med, New York, NY 10461 USA
[3] Montefiore Med Ctr, Dept Orthoped Surg, New York, NY 10461 USA
[4] Baystate Med Ctr, Dept Pathol, Springfield, MA 01199 USA
关键词
METAL-ON-METAL; TOTAL HIP-ARTHROPLASTY; CROSS-LINKED POLYETHYLENE; MOLECULAR-WEIGHT POLYETHYLENE; T-CELL-RECEPTOR; WEAR DEBRIS; PERIPROSTHETIC OSTEOLYSIS; IN-VIVO; RHEUMATOID-ARTHRITIS; NALP3; INFLAMMASOME;
D O I
10.1038/nrrheum.2011.128
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Joint replacement surgery is one of the success stories of modern medicine, restoring mobility, diminishing pain and improving the overall quality of life for millions of people. Unfortunately, wear of these prostheses over time generates debris, which activates an innate immune response that can ultimately lead to periprosthetic resorption of bone (osteolysis) and failure of the implant. Over the past decade, the biological interactions between the particulate debris from various implant materials and the immune system have begun to be better understood. The wear debris induces a multifaceted immune response encompassing the generation of reactive oxygen species and damage-associated molecular patterns, Toll-like receptor signaling and NALP3 inflammasome activation. Acting alone or in concert, these events generate chronic inflammation, periprosthetic bone loss and decreased osteointegration that ultimately leads to implant failure.
引用
收藏
页码:600 / 608
页数:9
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