Heme oxygenase: A target gene for anti-diabetic and obesity

被引：52

作者：

Abraham, N. G. ^{[1
]}

Tsenovoy, P. L. ^{[1
]}

McClung, J. ^{[1
]}

Drummond, G. S. ^{[1
]}

机构：

[1] New York Med Coll, Valhalla, NY 10595 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2008年 / 14卷 / 05期

关键词：

diabetes; carbon monoxide; bilirubin; HO-1; inflamation; TNF; IL-1; adiponectin;

D O I：

10.2174/138161208783597371

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.

引用

收藏

页码：412 / 421

页数：10

相关论文

共 141 条

[21] Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes - Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism [J].

Bruce, CR ;

Carey, AL ;

Hawley, JA ;

Febbraio, MA .

DIABETES, 2003, 52 (09) :2338-2345

[22]

*CDC, 2005, NAT DIAB FACT SHEET

[23] High glucose induces antioxidant enzymes in human endothelial cells in culture - Evidence linking hyperglycemia and oxidative stress [J].

Ceriello, A ;

delloRusso, P ;

Amstad, P ;

Cerutti, P .

DIABETES, 1996, 45 (04) :471-477

[24]

Chaldakov GN, 2007, CURR PHARM DESIGN, V13, P2176, DOI 10.2174/138161207781039616

[25] Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression [J].

Chauveau, C ;

Rémy, S ;

Royer, PJ ;

Hill, M ;

Tanguy-Royer, S ;

Hubert, FX ;

Tesson, L ;

Brion, R ;

Beriou, G ;

Gregoire, M ;

Josien, R ;

Cuturi, MC ;

Anegon, I .

BLOOD, 2005, 106 (05) :1694-1702

[26] Adiponectin stimulates production of nitric oxide in vascular endothelial cells [J].

Chen, H ;

Montagnani, M ;

Funahashi, T ;

Shimomura, I ;

Quon, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) :45021-45026

[27] Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway [J].

Chen, SF ;

Kapturczak, MH ;

Wasserfall, C ;

Glushakova, OY ;

Campbell-Thompson, M ;

Deshane, JS ;

Joseph, R ;

Cruz, PE ;

Hauswirth, WW ;

Madsen, KM ;

Croker, BP ;

Berns, KI ;

Atkinson, MA ;

Flotte, TR ;

Tisher, CC ;

Agarwal, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (20) :7251-7256

[28] Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: Therapeutic efficacy and mechanism of protection against type 1 diabetes [J].

Chen, W ;

Salojin, KV ;

Mi, QS ;

Grattan, M ;

Meagher, TC ;

Zucker, P ;

Delovitch, TL .

ENDOCRINOLOGY, 2004, 145 (02) :627-638

[29] The role of Fas in autoimmune diabetes [J].

Chervonsky, AV ;

Wang, Y ;

Wong, FS ;

Visintin, I ;

Flavell, RA ;

Janeway, CA ;

Matis, LA .

CELL, 1997, 89 (01) :17-24

[30] Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression [J].

Choi, BM ;

Pae, HO ;

Jeong, YR ;

Kim, YM ;

Chung, HT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 327 (04) :1066-1071

← 1 2 3 4 5 6 7 8 9 10 →