Studying cellular processes and detecting disease with protein microarrays

被引:24
作者
Zangar, RC [1 ]
Varnum, SM [1 ]
Bollinger, N [1 ]
机构
[1] Pacific NW Natl Lab, Richland, WA 99352 USA
关键词
protein; antibody; hapten; microarray; phosphotyrosine; immunoprofiling; kinase;
D O I
10.1080/03602530500205309
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Protein microarrays are a rapidly developing analytic tool with diverse applications in biomedical research. These applications include profiling of disease-markers or autoimmune responses, understanding molecular pathways, protein modifications, and protein activities. One factor that is driving this expanding usage is the wide variety of experimental formats that protein microarrays can take. In this review, we provide a short, conceptual overview of the different approaches for protein microarray. We then examine some of the most significant applications of these microarrays to date, with an emphasis on how global protein analyses can be used to facilitate biomedical research.
引用
收藏
页码:473 / 487
页数:15
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