Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

被引：313

作者：

Goel, A ^{[1
]}

Boland, CR ^{[1
]}

Chauhan, DP ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA

来源：

CANCER LETTERS | 2001年 / 172卷 / 02期

关键词：

curcumin; chemoprevention; colon cancer; cyclooxygenase-1; cyclooxygenase-2;

D O I：

10.1016/S0304-3835(01)00655-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anticancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of curcumin. Curcumin inhibited the cell growth of HT-29 cells in a concentration- and time-dependent manner. Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1. These data suggest that a non-toxic concentration of curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：111 / 118

页数：8

共 36 条

[1] NUTRITION INTERVENTION TRIALS IN LINXIAN, CHINA - SUPPLEMENTATION WITH SPECIFIC VITAMIN MINERAL COMBINATIONS, CANCER INCIDENCE, AND DISEASE-SPECIFIC MORTALITY IN THE GENERAL-POPULATION [J].

BLOT, WJ ;

LI, JY ;

TAYLOR, PR ;

GUO, WD ;

DAWSEY, S ;

WANG, GQ ;

YANG, CS ;

ZHENG, SF ;

GAIL, M ;

LI, GY ;

YU, Y ;

LIU, BQ ;

TANGREA, J ;

SUN, YH ;

LIU, FS ;

FRAUMENI, JF ;

ZHANG, YH ;

LI, B .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (18) :1483-1492

[2]

CAMPBELL WB, 1996, PHARMACOL BASIS THER, P601

[3]

Chinery R, 1998, CANCER RES, V58, P2323

[4] Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans [J].

Cryer, B ;

Feldman, M .

GASTROENTEROLOGY, 1999, 117 (01) :17-25

[5] PRIMARY STRUCTURE OF PROSTAGLANDIN-G/H SYNTHASE FROM SHEEP VESICULAR GLAND DETERMINED FROM THE COMPLEMENTARY-DNA SEQUENCE [J].

DEWITT, DL ;

SMITH, WL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1412-1416

[6] Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors [J].

DuBois, RN ;

Radhika, A ;

Reddy, BS ;

Entingh, AJ .

GASTROENTEROLOGY, 1996, 110 (04) :1259-1262

[7] EXPRESSION AND SELECTIVE-INHIBITION OF THE CONSTITUTIVE AND INDUCIBLE FORMS OF HUMAN CYCLOOXYGENASE [J].

GIERSE, JK ;

HAUSER, SD ;

CREELY, DP ;

KOBOLDT, C ;

RANGWALA, SH ;

ISAKSON, PC ;

SEIBERT, K .

BIOCHEMICAL JOURNAL, 1995, 305 :479-484

[8]

GREENWALD P, PRINCIPLES CHEMOPREV, P13

[9] Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway [J].

Hanif, R ;

Qiao, L ;

Shiff, SJ ;

Rigas, B .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1997, 130 (06) :576-584

[10] HUMAN CYCLOOXYGENASE-2 CDNA [J].

HLA, T ;

NEILSON, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7384-7388

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