Analytical techniques for solid-phase organic and combinatorial synthesis

In the developmental phase leading to solid-phase library generation, it is essential that reactions can be efficiently and readily optimized and quantified, and this requires reliable and sensitive techniques for the analysis of solid-phase reactions. The exploding interest in different types of solid-phase chemistry is placing increased demands on the reliability, diversity and sensitivity of such analytical methods. The authors describe the most exciting developments of the past 4-5 years.