Grading of chemotherapy-induced peripheral neurotoxicity using the Total Neuropathy Scale

被引:146
作者
Cavaletti, G
Bogliun, G
Marzorati, L
Zincone, A
Piatti, M
Colombo, N
Parma, G
Lissoni, A
Fei, F
Cundari, S
Zanna, C
机构
[1] Univ Milano Bicocca, Dipartimento Neurosci & Tecnol Biomed, Monza, Italy
[2] Univ Milano Bicocca, Dipartimento Sci Chirurg, Monza, Italy
[3] AO S Gerardo, Neurol Clin, Monza, Italy
[4] AO S Gerardo, Clin Ginecol, Monza, Italy
[5] Sigma Tau IFR, Pomezia, Italy
[6] Ist Europeo Oncol, Dipartimento Ginecol Oncol, Milan, Italy
关键词
D O I
10.1212/01.WNL.0000092015.03923.19
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors compared clinically based neurotoxicity scales with the Total Neuropathy Scale, with the aim of improving the grading of the severity of chemotherapy- induced peripheral neuropathy ( CIPN). The severity of CIPN was evaluated in a series of 60 women treated with cisplatin- and paclitaxel- based chemotherapy. A reduced version of TNS ( TNSr) was also compared. The authors concluded that the TNS and TNSr can be used to assess the severity of CIPN effectively, and the results of this evaluation can be reliably correlated with the oncologic grading of sensory peripheral neurotoxicity.
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页码:1297 / 1300
页数:4
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