Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-κB

被引：23

作者：

Huang, Gang ^{[1
]}

Yang, Yanchun ^{[2
]}

Xu, Zhizhen ^{[1
]}

Zhou, Peng ^{[1
]}

Gong, Wei ^{[1
]}

Li, Yuan ^{[1
]}

Fan, Jishan ^{[1
]}

He, Fengtian ^{[1
]}

机构：

[1] Third Mil Med Univ, Dept Biochem & Mol Biol, Coll Basic Med Sci, Chongqing 400038, Peoples R China

[2] Third Mil Med Univ, Southwest Hosp, Dept Oral & Maxillofacial Surg, Chongqing 400038, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2011年 / 650卷 / 01期

基金：

中国国家自然科学基金;

关键词：

B lymphocyte stimulator; Curcumin; NF kappa B; Autoimmune disease; CELL-ACTIVATING FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY SJOGRENS-SYNDROME; MULTIPLE-MYELOMA CELLS; RHEUMATOID-ARTHRITIS; CONSTITUTIVE ACTIVATION; ARTICULAR CHONDROCYTES; TRANSCRIPTION FACTORS; AUTOIMMUNE-DISEASES; GENE-EXPRESSION;

D O I：

10.1016/j.ejphar.2010.09.065

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Overexpression of B lymphocyte stimulator (BLyS) is closely involved in the pathogenesis and progression of some autoimmune diseases Curcumin a pharmacologically safe agent has been shown to possess potent anti-inflammatory properties However it is not clear whether curcumin affects the expression of BLyS In this study we report that curcumin inhibits the expression of BLyS and that a DNA-binding site for the transcriptional factor NF-kappa B in the BLyS promoter region is required for this regulation Moreover we find I hat curcumin reduces the DNA-binding activity of NF kappa B to the BLyS promoter region and suppresses nuclear translocation of p65 suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappa B signaling These results suggest that curcumin may serve as a novel therapeutic agent in the treatment of autoimmune diseases by targeting BLyS (C) 2010 Elsevier BV All rights reserved

引用

页码：451 / 457

页数：7

共 40 条

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