Apicomplexa in mammalian cells: Trafficking to the parasitophorous vacuole

被引：54

作者：

Cesbron-Delauw, Marie-France ^{[1
]}

Gendrin, Claire ^{[1
]}

Travier, Laetitia ^{[1
]}

Ruffiot, Pauline ^{[1
]}

Mercier, Corinne ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, Lab Adaptat & Pathogene Microorganismes, UMR 5163, F-38042 Grenoble 9, France

来源：

TRAFFIC | 2008年 / 9卷 / 05期

关键词：

Apicomplexa; dense granules; membranous nanotubular network; parasitophorous vacuole; Plasmodium spp; rhoptries; Toxoplasma gondii; tubovesicular network;

D O I：

10.1111/j.1600-0854.2008.00728.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components. Trafficking of parasite-encoded proteins destined to membrane compartments beyond the confine of the parasite plasma membrane is a process that offers a rich territory to explore novel mechanisms of protein-membrane interactions. Here, we focus on the PVs formed by the asexual stages of two pathogens of medical importance, Plasmodium and Toxoplasma. We compare the PVs of both parasites, with a particular emphasis on their evolutionary divergent compartmentalization within the host cell. We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post-secretory targeting of parasite proteins to the PV subcompartments.

引用

收藏

页码：657 / 664

页数：8

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