Screening natural products: Bioassay-directed isolation of active components by dual-mode CCC

被引:21
作者
Alvi, KA [1 ]
机构
[1] New Chem Entities Inc, Bothell, WA 98011 USA
关键词
D O I
10.1081/JLC-100104377
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In the search of new chemical entities, we have developed an integrated biological-physiochemical system for the identification of active compounds in fermentation broths. The system relies upon preliminary fractionation of the microbial crude extract by dual mode high-speed countercurrent (HSCCC, PC Inc.) couple with photodiode array (PDA) detection and bioassay.
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页码:1765 / 1773
页数:9
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