4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as potent anti-tumor agents

被引：103

作者：

Hayakawa, I

Shioya, R

Agatsuma, T

Furukawa, H

Naruto, S

Sugano, Y ^{[1
]}

机构：

[1] Sankyo Co Ltd, Exploratory Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Biomed Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[3] Sankyo Co Ltd, Res Informat Dept, Shinagawa Ku, Tokyo 1408710, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期

关键词：

anticancer;

D O I：

10.1016/j.bmcl.2003.10.039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on the structure of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester (1), which exhibits selective cytotoxicity against a tumorigenic cell line, (2,4-dimethoxyphenyl)-(4-hydroxy-3-methyl-6-phenylbenzofuran-2-yl)-methanone (18m) was designed and synthesized as a biologically stable derivative containing no ester group. Although the potency of 18m was almost the same as our initial hit compound 1, 18m is expected to last longer in the human body as an anticancer agent. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：455 / 458

页数：4

共 4 条

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