The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids

被引：95

作者：

Green, Joshua T. ^{[1
]}

Orr, Sarah K. ^{[1
]}

Bazinet, Richard P. ^{[1
]}

机构：

[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada

来源：

JOURNAL OF LIPID RESEARCH | 2008年 / 49卷 / 05期

关键词：

signaling; cyclooxygenase; lipoxygenase; docosanoid; neuroprotectin; uptake; turnover; kinetics; neuroinflammation; arachidonic acid;

D O I：

10.1194/jlr.R700017-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain phospholipids are highly enriched in docosahexaenoic acid (DHA; 22:6n-3). Recent advances indicate that 22:6n-3 is released from brain phospholipids via the action of phospholipase A(2) (PLA(2)) in response to several stimuli, including neurotransmission, where it then acts as a secondary messenger. Furthermore, it is now known that released 22:6n-3 is a substrate for several oxygenation enzymes whose products are potent signaling molecules. One emerging candidate PLA(2) involved in the release of 22:6n-3 from brain phospholipids is the group VI calcium-independent phospholipase A(2) (iPLA(2)). After a brief review of brain 22:6n-3 metabolism, cell culture and rodent studies facilitating the hypothesis that group VI iPLA(2) releases 22:6n-3 from brain phospholipids are discussed. The identification of PLA(2)s involved in cleaving 22:6n-3 from brain phospholipids could lead to the development of novel therapeutics for brain disorders in which 22:6n-3 signaling is disordered.

引用

页码：939 / 944

页数：6

共 92 条

[11] Lipid signaling in neural plasticity, brain repair, and neuroprotection [J].

Bazan, NG .

MOLECULAR NEUROBIOLOGY, 2005, 32 (01) :89-103

[12] Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: Relevance to bipolar disorder [J].

Bazinet, RP ;

Rao, JS ;

Chang, L ;

Rapoport, SI ;

Lee, HJ .

BIOLOGICAL PSYCHIATRY, 2006, 59 (05) :401-407

[13] Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder [J].

Bazinet, RP ;

Weis, MT ;

Rapoport, SI ;

Rosenberger, TA .

PSYCHOPHARMACOLOGY, 2006, 184 (01) :122-129

[14] Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat [J].

Bazinet, RP ;

Rao, JS ;

Chang, L ;

Rapoport, SI ;

Lee, HJ .

PSYCHOPHARMACOLOGY, 2005, 182 (01) :180-185

[15]

Bonventre JV, 2002, ADV EXP MED BIOL, V507, P25

[16] Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models [J].

Bosetti, Francesca .

JOURNAL OF NEUROCHEMISTRY, 2007, 102 (03) :577-586

[17] Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model [J].

Calon, F ;

Lim, GP ;

Yang, FS ;

Morihara, T ;

Teter, B ;

Ubeda, O ;

Rostaing, P ;

Triller, A ;

Salem, N ;

Ashe, KH ;

Frautschy, SA ;

Cole, GM .

NEURON, 2004, 43 (05) :633-645

[18] Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: Evidence from animal studies [J].

Calon, Frederic ;

Cole, Greg .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2007, 77 (5-6) :287-293

[19] Phospholipase A2 isoforms:: a perspective [J].

Chakraborti, S .

CELLULAR SIGNALLING, 2003, 15 (07) :637-665

[20] The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations [J].

Chen, Chuck T. ;

Ma, David W. L. ;

Kim, John H. ;

Mount, Howard T. J. ;

Bazinet, Richard P. .

JOURNAL OF LIPID RESEARCH, 2008, 49 (01) :147-152

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