T4 phage photoinactivation by linear furocournarins and angular furoquinolinones

被引：1

作者：

Bettio, Frazia ^{[1
]}

Baccichetti, Francarosa ^{[1
]}

Simonato, Morena ^{[1
]}

Marzano, Cristina ^{[1
]}

Bordin, Franco ^{[1
]}

机构：

[1] Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

来源：

CHEMMEDCHEM | 2006年 / 1卷 / 05期

关键词：

Bifunctional lesions; Furocoumarins; Photochemistry; Photosensitizers; T4; bacteriophage;

D O I：

10.1002/cmdc.200500084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

TMP, FQ, and HFQ kill T4 phage under mild experimental conditions in its virion form, but not in its vegetative form. The process occurs through a two-step irradiation procedure, characteristic of DNA bifunctional lesions. We hypothesize the induction of DNA-protein cross-links in mature phages that can inhibit the infection process.

引用

页码：525 / +

页数：4

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