Distribution and excretion of TEGDMA in guinea pigs and mice

被引:40
作者
Reichl, FX
Durner, J
Hickel, R
Kunzelmann, KH
Jewett, A
Wang, MY
Spahl, W
Kreppel, H
Moes, GW
Kehe, K
Walther, U
Forth, W
Hume, WR [1 ]
机构
[1] Univ Calif Los Angeles, Dent Res Inst, Los Angeles, CA 90095 USA
[2] Univ Munich, Walther Straub Inst Pharmacol & Toxicol, D-80336 Munich, Germany
[3] Univ Munich, Dept Operat Restorat Dent Periodontol & Pedodont, D-80336 Munich, Germany
[4] Univ Munich, Inst Organ Chem, D-81377 Munich, Germany
[5] TNO, Prins Maurits Lab, NL-2280 AA Rijswijk, Netherlands
[6] Sanit Akad Bundeswehr, Inst Pharmacol & Toxicol, D-80937 Munich, Germany
关键词
TEGDMA; composite resin; restorative materials; toxicity;
D O I
10.1177/00220345010800050501
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of C-14-TEGDMA applied via gastric, intradermal, and intravenous administration at dose levels well above those encountered in dental care were examined in vivo in guinea pigs and mice as a test of the hypothesis that TEGDMA reaches cytotoxic levels in mammalian tissues. C-14-TEGDMA was taken up rapidly from the stomach and small intestine after gastric administration in both species and was widely distributed in the body following administration by each route. Most C-14 was excreted within one day as (CO2)-C-14. The peak equivalent TEGDMA levels in all mouse and guinea pig tissues examined were at least 1000-fold less than known toxic levels. The study therefore did not support the hypothesis.
引用
收藏
页码:1412 / 1415
页数:4
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