The metabolic effects of native and transgenic hemoglobins on plants

被引：30

作者：

Bülow, L

Holmberg, N

Lilius, G

Bailey, JE

机构：

[1] Ctr Chem & Chem Engn, Dept Pure & Appl Biochem, S-22100 Lund, Sweden

[2] Swiss Fed Inst Technol, Inst Biotechnol, CH-8093 Zurich, Switzerland

来源：

TRENDS IN BIOTECHNOLOGY | 1999年 / 17卷 / 01期

关键词：

D O I：

10.1016/S0167-7799(98)01252-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The strictly aerobic bacterium Vitreoscilla expresses a hemoglobin-like protein, VHb, when subjected to oxygen stress. When expressed in plants, this has several intriguing physiological effects, such as improving the overall growth rate, speeding germination and flowering, and increasing the productivity of certain oxygen-requiring metabolic pathways. Although the mechanisms behind the effects of VHb in heterologous hosts are not yet fully characterized, it has been suggested that VHb facilitates oxygen transport and/or storage. This hypothesis is supported by the kinetic properties of VHb, which allow very rapid dissociation of oxygen from the protein.

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页码：21 / 24

页数：4

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[21] Transgenic tobacco expressing Vitreoscilla hemoglobin exhibits enhanced growth and altered metabolite production [J].

Holmberg, N ;

Lilius, G ;

Bailey, JE ;

Bulow, L .

NATURE BIOTECHNOLOGY, 1997, 15 (03) :244-247

[22] Expression of Vitreoscilla hemoglobin is superior to horse heart myoglobin or yeast flavohemoglobin expression for enhancing Escherichia coli growth in a microaerobic bioreactor [J].

Kallio, PT ;

Tsai, PS ;

Bailey, JE .

BIOTECHNOLOGY PROGRESS, 1996, 12 (06) :751-757

[23] INTRACELLULAR EXPRESSION OF VITREOSCILLA HEMOGLOBIN ALTERS ESCHERICHIA-COLI ENERGY-METABOLISM UNDER OXYGEN-LIMITED CONDITIONS [J].

KALLIO, PT ;

KIM, DJ ;

TSAI, PS ;

BAILEY, JE .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 219 (1-2) :201-208

[24]

KHOSLA C, 1990, BIO-TECHNOL, V8, P849, DOI 10.1038/nbt0990-849

[25] THE VITREOSCILLA HEMOGLOBIN GENE - MOLECULAR-CLONING, NUCLEOTIDE-SEQUENCE AND GENETIC EXPRESSION IN ESCHERICHIA-COLI [J].

KHOSLA, C ;

BAILEY, JE .

MOLECULAR & GENERAL GENETICS, 1988, 214 (01) :158-161

[26] HETEROLOGOUS EXPRESSION OF A BACTERIAL HEMOGLOBIN IMPROVES THE GROWTH-PROPERTIES OF RECOMBINANT ESCHERICHIA-COLI [J].

KHOSLA, C ;

BAILEY, JE .

NATURE, 1988, 331 (6157) :633-635

[27] ORGAN REGULATED EXPRESSION OF THE PARASPONIA-ANDERSONII HEMOGLOBIN GENE IN TRANSGENIC TOBACCO PLANTS [J].

LANDSMANN, J ;

LLEWELLYN, D ;

DENNIS, ES ;

PEACOCK, WJ .

MOLECULAR & GENERAL GENETICS, 1988, 214 (01) :68-73

[28] ACTINORHODIN PRODUCTION BY STREPTOMYCES-COELICOLOR AND GROWTH OF STREPTOMYCES-LIVIDANS ARE IMPROVED BY THE EXPRESSION OF A BACTERIAL HEMOGLOBIN [J].

MAGNOLO, SK ;

LEENUTAPHONG, DL ;

DEMODENA, JA ;

CURTIS, JE ;

BAILEY, JE ;

GALAZZO, JL ;

HUGHES, DE .

BIO-TECHNOLOGY, 1991, 9 (05) :473-476

[29]

MATSUDA J, 1991, J BIOL CHEM, V266, P9460

[30] EFFECT OF VITREOSCILLA HEMOGLOBIN EXPRESSION ON GROWTH AND SPECIFIC TISSUE-PLASMINOGEN ACTIVATOR PRODUCTIVITY IN RECOMBINANT CHINESE-HAMSTER OVARY CELLS [J].

PENDSE, GJ ;

BAILEY, JE .

BIOTECHNOLOGY AND BIOENGINEERING, 1994, 44 (11) :1367-1370

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