Drug therapy: Antithyroid drugs

被引：769

作者：

Cooper, DS ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sinai Hosp Baltimore, Div Endocrinol, Baltimore, MD 21215 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2005年 / 352卷 / 09期

关键词：

D O I：

10.1056/NEJMra042972

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Six decades after their introduction, antithyroid drugs continue to be important in the management of hyperthyroidism. Patients with Graves' disease, who have an approximately 40 to 50 percent chance of remission after 12 to 18 months of therapy, are the best candidates. Antithyroid drugs are deceptively easy to use, but because of the variability in the response of patients and the potentially serious side effects, all practitioners who prescribe the drugs need to have a working knowledge of their complex pharmacology.

引用

页码：905 / 917

页数：13

共 134 条

[81] METHIMAZOLE - AN ALTERNATIVE ROUTE OF ADMINISTRATION [J].

NABIL, N ;

MINER, DJ ;

AMATRUDA, JM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1982, 54 (01) :180-181

[82] Antithyroid drugs inhibit radioiodine-induced increases in thyroid autoantibodies in hyperthyroid Graves' disease [J].

Nakazato, N ;

Yoshida, K ;

Mori, K ;

Kiso, Y ;

Sayama, N ;

Tani, JI ;

Nakagawa, Y ;

Ito, S .

THYROID, 1999, 9 (08) :775-779

[83] Predictors of outcome and comparison of different drug regimens for the prevention of relapse in patients with Graves' disease [J].

Nedrebo, BG ;

Holm, PI ;

Uhlving, S ;

Sorheim, JI ;

Skeie, S ;

Eide, GE ;

Husebye, ES ;

Lien, EA ;

Aanderud, S .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2002, 147 (05) :583-589

[84] SINGLE DAILY DOSE OF METHIMAZOLE COMPARED TO EVERY 8 HOURS PROPYLTHIOURACIL IN THE TREATMENT OF HYPERTHYROIDISM [J].

NICHOLAS, WC ;

FISCHER, RG ;

STEVENSON, RA ;

BASS, JD .

SOUTHERN MEDICAL JOURNAL, 1995, 88 (09) :973-976

[85] A comparison of 20 or 40 mg per day of carbimazole in the initial treatment of hyperthyroidism [J].

Page, SR ;

Sheard, CE ;

Herbert, M ;

Hopton, M .

CLINICAL ENDOCRINOLOGY, 1996, 45 (05) :511-515

[86]

Page SR, 1997, CLIN ENDOCRINOL, V46, P240

[87]

PARKER W A, 1982, Clinical Pharmacy, V1, P471

[88] METHIMAZOLE HAS NO DOSE-RELATED EFFECT ON THE INTENSITY OF THE INTRATHYROIDAL AUTOIMMUNE PROCESS IN RELAPSING GRAVES-DISEASE [J].

PASCHKE, R ;

VOGG, M ;

KRISTOFERITSCH, R ;

AKTUNA, D ;

WAWSCHINEK, O ;

EBER, O ;

USADEL, KH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (08) :2470-2474

[89] Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK [J].

Pearce, SHS .

CLINICAL ENDOCRINOLOGY, 2004, 61 (05) :589-594

[90] Suppression of serum thyrotropin with thyroxine in patients with Graves' disease: Effects on recurrence of hyperthyroidism and thyroid volume [J].

Pfeilschifter, J ;

Ziegler, R .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1997, 136 (01) :81-86

← 4 5 6 7 8 9 10 11 12 13 →