Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

被引：365

作者：

Suh, BC ^{[1
]}

Hille, B ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.conb.2005.05.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phosphaticlylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphaticlylinositol 4,5bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.

引用

页码：370 / 378

页数：9

共 66 条

[51] Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors
Selyanko, AA
Hadley, JK
Wood, IC
Abogadie, FC
Jentsch, TJ
Brown, DA
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 2000, 522 (03): : 349 - 355
[52] Membrane phospholipid control of nucleotide sensitivity of KATP channels
Shyng, SL
Nichols, CG
[J]. SCIENCE, 1998, 282 (5391) : 1138 - 1141
[53] Ras activates the epithelial Na+ channel through phosphoinositide 3-OH kinase signaling
Staruschenko, A
Patel, P
Tong, QS
Medina, JL
Stockand, JD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (36) : 37771 - 37778
[54] Regulation of KCNQ2/KCNQ3 current by G protein cycling:: The kinetics of receptor-mediated signaling by Gq
Suh, BC
Horowitz, LF
Hirdes, W
Mackie, K
Hille, B
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 2004, 123 (06) : 663 - 683
[55] Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis
Suh, BC
Hille, B
[J]. NEURON, 2002, 35 (03) : 507 - 520
[56] Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates
Sui, JL
Petit-Jacques, J
Logothetis, DE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) : 1307 - 1312
[57] Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
Takezawa, R
Schmitz, C
Demeuse, P
Scharenberg, AM
Penner, R
Fleig, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) : 6009 - 6014
[58] Dynamics of phosphatidylinositol 4,5-bisphosphate in actin-rich structures
Tall, EG
Spector, I
Pentyala, SN
Bitter, I
Rebecchi, MJ
[J]. CURRENT BIOLOGY, 2000, 10 (12) : 743 - 746
[59] Direct activation of the epithelial Na+ channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase
Tong, QS
Gamper, N
Medina, JL
Shapiro, MS
Stockand, JD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (21) : 22654 - 22663
[60] Receptor tyrosine kinases mediate epithelial Na+ channel inhibition by epidermal growth factor
Tong, QS
Stockand, JD
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 288 (01) : F150 - F161

← 1 2 3 4 5 6 7 →