Neural transplantation for Parkinson's disease

被引：12

作者：

Date, I ^{[1
]}

Ohmoto, T ^{[1
]}

机构：

[1] Okayama Univ, Dept Neurol Surg, Okayama 700, Japan

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1999年 / 19卷 / 01期

关键词：

neural transplantation; Parkinson's disease; dopamine; adrenal medulla; chromaffin cell; cryopreservation; encapsulated cell grafting;

D O I：

10.1023/A:1006964507916

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. Neural transplantation is one promising approach for the treatment of Parkinson's disease. Fetal substantia nigra cells are a good source of dopamine, but in order to avoid ethical and immunological problems, adrenal medullary chromaffin cells have been investigated as an alternative sourer. 2. Grafted adrenal medullary chromaffin cells can provide dopamine as well as several neurotrophic factors that affect dopaminergic neurons in the brain. 3. We review experimental studies for application of neural transplantation techniques in Parkinson's disease, including immunological studies, cryopreservation, microvasculature, donor tissue, and direct gene delivery studies performed in our laboratory. Our clinical experience and new approach involving a polymer-encapsulated cell grafting procedure are also described.

引用

收藏

页码：67 / 78

页数：12

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