Common Molecular Cytogenetic Pathway in Papillary Tumors of the Pineal Region (PTPR)

被引：22

作者：

Gutenberg, Angelika ^{[1
]}

Brandis, Almuth ^{[4
]}

Hong, Bujung ^{[3
]}

Gunawan, Bastian ^{[2
]}

Enders, Christina ^{[2
]}

Schaefer, Inga-Marie ^{[2
]}

Burger, Ralf ^{[5
]}

Ostertag, Helmut ^{[6
]}

Gaab, Michael ^{[5
]}

Krauss, Joachim K. ^{[3
]}

Fuezesi, Laszlo ^{[2
]}

机构：

[1] Univ Gottingen, Dept Neurosurg, D-37099 Gottingen, Germany

[2] Univ Gottingen, Dept Pathol, D-37099 Gottingen, Germany

[3] Hannover Med Sch, Dept Neurosurg, D-3000 Hannover, Germany

[4] Hannover Med Sch, Dept Pathol, D-3000 Hannover, Germany

[5] Klinikum Hannover Nordstadt, Dept Neurosurg, Hannover, Germany

[6] Klinikum Hannover Nordstadt, Dept Pathol, Hannover, Germany

来源：

BRAIN PATHOLOGY | 2011年 / 21卷 / 06期

关键词：

CGH; papillary tumor; pineal region; COMPARATIVE GENOMIC HYBRIDIZATION; GAMMA-KNIFE RADIOSURGERY; CHROMOSOMAL IMBALANCES; MALIGNANT PROGRESSION; PROGNOSIS; FEATURES; CLASSIFICATION; ABNORMALITIES; MENINGIOMAS; EPENDYMOMAS;

D O I：

10.1111/j.1750-3639.2011.00493.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Primary papillary tumors of the central nervous system and particularly the pineal region are rare. Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization Classification of Tumors of the Nervous System. Because of their rarity, further pheno- and genotypical observations as well as therapeutic experience are necessary to differentiate PTPR from other primary or secondary papillary tumors of this region. We herein present three cases of PTPR characterized by local recurrence in two of them. Primary and recurrent tumors were analyzed by immunohistochemistry and comparative genomic hybridization (CGH). From our results clonal chromosomal aberrations can be postulated which seem to be a feasible tool to differentiate PTPRs from other primary or secondary papillary tumors of this region.

引用

页码：672 / 677

页数：6

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