Versatility from Protein Disorder

被引:187
作者
Babu, M. Madan [1 ]
Kriwacki, Richard W. [2 ]
Pappu, Rohit V. [3 ]
机构
[1] MRC Lab Mol Biol, Cambridge CB2 0QH, England
[2] St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA
[3] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA
基金
英国医学研究理事会; 美国国家科学基金会;
关键词
INTRINSICALLY UNSTRUCTURED PROTEINS; RECOGNITION; CHARGE; MOTIFS;
D O I
10.1126/science.1228775
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1460 / 1461
页数:2
相关论文
共 16 条
[1]   Intrinsically disordered proteins: regulation and disease [J].
Babu, M. Madan ;
van der Lee, Robin ;
de Groot, Natalia Sanchez ;
Gsponer, Joerg .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2011, 21 (03) :432-440
[2]   Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks [J].
Buljan, Marija ;
Chalancon, Guilhem ;
Eustermann, Sebastian ;
Wagner, Gunter P. ;
Fuxreiter, Monika ;
Bateman, Alex ;
Babu, M. Madan .
MOLECULAR CELL, 2012, 46 (06) :871-883
[3]   Evolution of the protein repertoire [J].
Chothia, C ;
Gough, J ;
Vogel, C ;
Teichmann, SA .
SCIENCE, 2003, 300 (5626) :1701-1703
[4]   Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions [J].
Crick, Scott L. ;
Jayaraman, Murali ;
Frieden, Carl ;
Wetzel, Ronald ;
Pappu, Rohit V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16764-16769
[5]   Attributes of short linear motifs [J].
Davey, Norman E. ;
Van Roey, Kim ;
Weatheritt, Robert J. ;
Toedt, Grischa ;
Uyar, Bora ;
Altenberg, Brigitte ;
Budd, Aidan ;
Diella, Francesca ;
Dinkel, Holger ;
Gibson, Toby J. .
MOLECULAR BIOSYSTEMS, 2012, 8 (01) :268-281
[6]   Intrinsically unstructured proteins and their functions [J].
Dyson, HJ ;
Wright, PE .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (03) :197-208
[7]   Regulation of cell division by intrinsically unstructured proteins: Intrinsic flexibility, modularity, and signaling conduits [J].
Galea, Charles A. ;
Wang, Yuefeng ;
Sivakolundu, Sivashankar G. ;
Kriwacki, Richard W. .
BIOCHEMISTRY, 2008, 47 (29) :7598-7609
[8]   Phase transitions in the assembly of multivalent signalling proteins [J].
Li, Pilong ;
Banjade, Sudeep ;
Cheng, Hui-Chun ;
Kim, Soyeon ;
Chen, Baoyu ;
Guo, Liang ;
Llaguno, Marc ;
Hollingsworth, Javoris V. ;
King, David S. ;
Banani, Salman F. ;
Russo, Paul S. ;
Jiang, Qiu-Xing ;
Nixon, B. Tracy ;
Rosen, Michael K. .
NATURE, 2012, 483 (7389) :336-U129
[9]   Net charge per residue modulates conformational ensembles of intrinsically disordered proteins [J].
Mao, Albert H. ;
Crick, Scott L. ;
Vitalis, Andreas ;
Chicoine, Caitlin L. ;
Pappu, Rohit V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8183-8188
[10]  
Mitrea D. M., 2012, PAC S BIOCOMPUT, V17, P152