MR-based in vivo hippocampal volumetrics:: 2.: Findings in neuropsychiatric disorders

被引:303
作者
Geuze, E
Vermetten, E
Bremner, JD
机构
[1] Cent Mil Hosp, Dept Mil Psychiat, NL-3584 CX Utrecht, Netherlands
[2] Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3508 TA Utrecht, Netherlands
[3] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA
[4] Emory Univ, Sch Med, Dept Behav Sci & Radiol, Atlanta, GA 30322 USA
[5] Ctr Positron Emiss Tomog, Decatur, GA USA
[6] Atlanta VAMC, Decatur, GA USA
关键词
hippocampus; MRI; volume; neurology; psychiatry;
D O I
10.1038/sj.mp.4001579
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Magnetic resonance imaging (MRI) has opened a new window to the brain. Measuring hippocampal volume with MRI has provided important information about several neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. Smaller hippocampal volumes have been reported in epilepsy, Alzheimer's disease, dementia, mild cognitive impairment, the aged, traumatic brain injury, cardiac arrest, Parkinson's disease, Huntington's disease, Cushing's disease, herpes simplex encephalitis, Turner's syndrome, Down's syndrome, survivors of low birth weight, schizophrenia, major depression, posttraumatic stress disorder, chronic alcoholism, borderline personality disorder, obsessive - compulsive disorder, and antisocial personality disorder. Significantly larger hippocampal volumes have been correlated with autism and children with fragile X syndrome. Preservation of hippocampal volume has been reported in congenital hyperplasia, children with fetal alcohol syndrome, anorexia nervosa, attention-deficit and hyperactivity disorder, bipolar disorder, and panic disorder. Possible mechanisms of hippocampal volume loss in neuropsychiatric disorders are discussed.
引用
收藏
页码:160 / 184
页数:25
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