Lack of correlation between heparin dose and standard clinical monitoring tests in treatment with unfractionated heparin in critically III children

被引：63

作者：

Kuhle, Stefan ^{[1
,2
]}

Eulmesekian, Pablo ^{[3
,4
]}

Kavanagh, Brian

Massicotte, Patricia ^{[6
]}

Vegh, Patsy ^{[5
]}

Lau, Alice ^{[5
]}

Mitchell, Lesley G. ^{[5
,6
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Populat Hlth Sci, Div Haematol Oncol, Toronto, ON, Canada

[2] Univ Toronto, Hosp Sick Children, Div Hematol Oncol, Toronto, ON, Canada

[3] Univ Toronto, Hosp Sick Children, Dept Crit Care Med, Toronto, ON, Canada

[4] Univ Toronto, Hosp Sick Children, Dept Anesthesia, Toronto, ON, Canada

[5] Univ Toronto, Hosp Sick Children, Dept Populat Hlth Sci, Toronto, ON, Canada

[6] Univ Alberta, Stoller Childrens Hosp, Dept Pediat, Edmonton, AB, Canada

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 04期

基金：

奥地利科学基金会;

关键词：

unfractionated heparin; children; monitoring;

D O I：

10.3324/haematol.10696

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The activated partial thromboplastin time (aPTT) and anti-Xa activity are used for monitoring unfractionated heparin (UFH) therapy in children and may not be optimal. Objective: Determine correlations of aPTT, anti-Xa and UFH dose in children. Single centre prospective cohort study in children receiving UFH. The aPTT and anti-Xa results from routine coagulation monitoring were collected. Thirty-nine children (median age 18 days) were enrolled. There was no relationship between aPTT and UFH dose (r(2)=0.12) or anti-Xa and UFH dose (r(2)=0.03) or aPTT and anti-Xa (r(2)=0.22). aPTT and anti-Xa do not accurately monitor UFH therapy in children.

引用

页码：554 / 557

页数：4

共 15 条

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